The inhalation exposure to Stachybotrys chartarum(SC) has been playing a critical role in public health domain due to its ability to produce toxins (trichothecene and other mycotoxins), that are implicated in the cases of acute idiopathic pulmonary hemorrhages (AIPH) in infants.
Acute Inflammatory Responses to Stachybotrys chartarum in the Lungs of Infant Rats:Time Course and Possible Mechanisms. Dorr Dearborn. Iwona Yike. Thomas Rand. Dorr Dearborn. Iwona Yike. Thomas Rand. Related Papers. Stachybotrys chartarum, Trichothecene Mycotoxins, and Damp Building-Related Illness:New Insights into a Public Health Enigma. Acute Inflammatory Responses to Stachybotrys chartarum in Jan 12, 2005 · Stachybotrys chartarum has been linked to building-related respiratory problems including pulmonary hemorrhage in infants. The macrocyclic trichothecenes produced by S. chartarum have been the primary focus of many investigations.
Moisture-damaged interior surfaces in both buildings were contaminated with S. chartarum, A. versicolor, and Penicillium species. Aspergillus species, especially A. versicolor, at concentrations of 10(1) to 10(4)/m3 dominated the indoor air under normal operating conditions. Bulk samples also revealed large quantities of Stachybotrys. Comparison of Inflammatory and Cytotoxic Lung Responses Advance Access publication January Comparison of Inflammatory and Cytotoxic Lung Responses in Mice after Intratracheal Exposure to Spores of Two Different Stachybotrys chartarum Strains J. Flemming 0 B. Hudson 0 T. G. Rand 0 0 Department of Biology, Saint Mary's University , 923 Robie St., Halifax, Nova Scotia , Canada B3H 3C3 Stachybotrys chartarum is an important toxigenic fungus
Her research focuses on pulmonary and cellular inflammatory responses to the toxic mold Stachybotrys chartarum and its mycotoxins. Lichtenstein teaches SC210 Human Health and Disease, SC211 Food and Nutrition, SC212 Evolution of Human Nature, and SC216 DNA and Society. Jamie Rosenblum Lichtenstein - Adjunct Professor - Emerson Strain differences influence murine pulmonary responses to Stachybotrys chartarum Am J Respir Cell Mol Biol. Oct 2006 When the fungus Stachybotrys chartarum is inhaled, its mycotoxins may cause
Pulmonary responses to Stachybotrys chartarum and its toxins:Mouse strain affects clearance and macrophage cytotoxicity. Toxicol Sci. 2010 Jul;116(1):113-21. Molina RM, Phattanarudee S, Kim J, Thompson K, Wessling-Resnick M, Maher TJ, Brain JD. Publications Joseph Brain Harvard T.H. Chan School of Aug 27, 2012 · Pulmonary responses to Stachybotrys chartarum and its toxins:Mouse strain affects clearance and macrophage cytotoxicity. Toxicol Sci. 2010 Jul;116(1):113-21. Molina RM, Phattanarudee S, Kim J, Thompson K, Wessling-Resnick M, Maher TJ, Brain JD.
Apr 20, 2021 · In June 1997, a CDC scientific task force, in a review of the agency's response to the problem, advised the CDC director that concerns about the role of S. chartarum in pulmonary hemorrhage needed Reduction of pulmonary toxicity of Stachybotrys chartarum Jul 01, 2000 · Acute exposure to Stachybotrys chartarum spores results in severe pulmonary injury in animal models (15, 16, 21).Although several outbreaks of illness in humans have been attributed to respiratory exposure to S. chartarum, the causal link between fungal contamination in the indoor environment and adverse pulmonary effects has yet to be firmly established (46, 9, 13, 25).
Although not commonly associated with bioaerosol exposure, a U.S. Centers for Disease Control and Prevention (CDC) report suggested that exposure to Stachybotrys chartarum was the cause of a cluster of acute pulmonary hemorrhage in 10 infants presenting at the Cleveland children's hospital in 199394 (CDC, 1994, 1997; Etzel et al., 1998).Pulmonary Responses to Stachybotrys chartarum and Its Mar 31, 2010 · There exists strong evidence that S. chartarum causes acute inflammatory responses, macrophage cytotoxicity , pulmonary hemorrhage , lung inflammation [29,30] and asthma-like responses